解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::One of the most basic computational elements within a circuit is the synapse across which signals are transferred. Here we summarize some experimental strategies that allow the synaptic basis of circuit function to be studied through imaging. The two most promising approaches available currently are pHluorin-based rep...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2009.051953
更新日期:2011-01-01 00:00:00
abstract::The uptake and distribution of CO throughout the circulatory system during two different methods of CO rebreathing (2 min 'Schmidt' and 40 min 'Burge' methods) were determined in nine healthy volunteers. Specifically, the impact of (i) differences in circulatory mixing time (t(mix)), (ii) CO diffusion to myoglobin (Mb...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.054031
更新日期:2010-12-01 00:00:00
abstract::The sympathetic neural regulation of the cerebral circulation remains controversial. The purpose of the present study was to determine how exercise modulates the simultaneous responsiveness of the cerebral and brachial circulations to 'endogenous' sympathetic activation (cold pressor test). In nine healthy subjects, h...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.054387
更新日期:2010-11-01 00:00:00
abstract::Brain blood vessels contain muscarinic receptors that are important for cerebral blood flow (CBF) regulation, but whether a cholinergic receptor mechanism is involved in the exercise-induced increase in cerebral perfusion or affects cerebral metabolism remains unknown. We evaluated CBF and cerebral metabolism (from ar...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2010.054346
更新日期:2010-10-01 00:00:00
abstract::We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) H...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.053090
更新日期:2010-09-01 00:00:00
abstract::The renin-angiotensin system is activated in the early phase of two-kidney, one-clip (2K-1C) hypertension. The paraventricular nucleus (PVN) integrates inputs regulating sympathetic outflow. The PVN receives inputs from plasma angiotensin II via projections from circumventricular organs and from renal afferent nerves ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.051789
更新日期:2010-08-01 00:00:00
abstract::Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.051029
更新日期:2010-06-01 00:00:00
abstract::Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.047399
更新日期:2010-05-01 00:00:00
abstract::Severe-intensity constant-work-rate exercise results in the attainment of maximal oxygen uptake, but the muscle metabolic milieu at the limit of tolerance (T(lim)) for such exercise remains to be elucidated. We hypothesized that T(lim) during severe-intensity exercise would be associated with the attainment of consist...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2009.050500
更新日期:2010-04-01 00:00:00
abstract::Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.050682
更新日期:2010-04-01 00:00:00
abstract::The effects of direct autonomic nerve stimulation on the heart may be quite different to those of perfusion with pharmacological neuromodulating agents. This study was designed to investigate the effect of autonomic nerve stimulation on intracellular calcium fluorescence using fura-2 AM in the isolated Langendorff-per...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.048215
更新日期:2010-01-01 00:00:00
abstract::A great deal of knowledge exists regarding neural control of myocardial function in the rat. Most of the studies addressing this issue were conducted either under general anaesthesia or in isolated hearts in vitro. Our principal aim was to provide a detailed quantitative description of mechanisms controlling cardiac c...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.048710
更新日期:2010-01-01 00:00:00
abstract::Appreciation for the role of aldosterone and mineralocorticoid receptors in cardiovascular disease is accelerating rapidly. Recent experimental work has unveiled a strong relationship between brain mineralocorticoid receptors and sympathetic drive, an important determinant of outcome in heart failure and hypertension....
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2008.045948
更新日期:2010-01-01 00:00:00
abstract::5-[5-(2-Nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (UCF-101) is a protease inhibitor which was reported to protect against ischaemic heart damage and apoptosis. This study evaluated the impact of UCF-101 on steptozotocin (STZ)-induced diabetic cardiomyocyte dysfunction. Adult FVB mice were made di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.049189
更新日期:2009-09-01 00:00:00
abstract::The objective of this study was to examine the potential of stearic acid to induce cardiomyocyte cell death and the hypothesis that the amount of cellular lipid is a determinant of cell death. In cardiomyocytes from embryonic chick heart, stearic acid (SA) produced a significant (P < 0.001) concentration-dependent inc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.048082
更新日期:2009-08-01 00:00:00
abstract::The aim of the present study was to assess the influence of body posture on post-submaximal exercise parasympathetic reactivation and to examine whether this influence was preserved under a heightened sympathetic background. On four occasions, eleven moderately trained subjects (22.1 +/- 3.0 years old) performed, in r...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2009.048041
更新日期:2009-07-01 00:00:00
abstract::In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...
journal_title:Experimental physiology
pub_type:
doi:10.1113/expphysiol.2008.046359
更新日期:2009-06-01 00:00:00
abstract::This work was undertaken to study the effect of pectin feeding on the expression level, cellular localization and functional activity of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of rats. The results indicated that MCT1 protein level was significantly increased along the entire length of the g...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.046797
更新日期:2009-04-01 00:00:00
abstract::Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.043281
更新日期:2009-04-01 00:00:00
abstract::Age is a primary risk factor for cardiovascular disease, and this is an increasingly important public health concern because of an increase in the absolute number and proportion of the population at an older age in many countries. A key component of cardiovascular ageing is reduced function of the vascular endothelium...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2008.043349
更新日期:2009-03-01 00:00:00
abstract::Joint movement was recently shown to stimulate the secretion of the lubricant hyaluronan (HA); also, exercise therapy and intra-articular hyaluronan injections are used to treat moderate osteoarthritis. The present study quantifies the stimulus-response curves for HA secretion in vivo and reports a role of transcripti...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.045203
更新日期:2009-03-01 00:00:00
abstract::Obstructive sleep apnoea (OSA) leads to chronic intermittent hypoxia (CIH) during sleep. Obstructive sleep apnoea has been associated with liver injury. Acetaminophen (APAP; known as paracetamol outside the USA) is one of the most commonly used drugs which has known hepatotoxicity. The goal of the present study was to...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.044883
更新日期:2009-02-01 00:00:00
abstract::Adenosine 5'-triphosphate (ATP) is a cotransmitter with classical transmitters in most nerves in the peripheral and central nervous systems, although the proportions vary between tissues and species and in different developmental and pathophysiological circumstances. There was early evidence that ATP was released toge...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.043620
更新日期:2009-01-01 00:00:00
abstract::To probe the mechanisms by which respiratory syncytial virus (RSV) infection in early life forms an important risk factor for the development of chronic asthma, an airway hyper-responsiveness (AHR) animal model of guinea-pigs with persistent RSV infection was established by intranasal instillation of 2 x 10(5) plaque-...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.043521
更新日期:2008-12-01 00:00:00
abstract::Contraction-mediated injury is a major contributing factor to the pathophysiology of muscular dystrophy and therefore therapies that can attenuate this type of injury have clinical relevance. Systemic administration of insulin-like growth factor-I (IGF-I) has been shown to improve muscle function in dystrophic mdx mic...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.042838
更新日期:2008-11-01 00:00:00
abstract::It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.042895
更新日期:2008-10-01 00:00:00
abstract::We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.041285
更新日期:2008-07-01 00:00:00
abstract::Recently, we reported the presence of a local renal aldosterone production. In the present study, we tested the hypothesis that local aldosterone production in the kidney contributes to renal inflammation, matrix formation and albuminuria associated with diabetes. We evaluated changes in renal aldosterone content (RAC...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.042085
更新日期:2008-07-01 00:00:00
abstract::Although numerous studies have recently implicated the calcineurin-nuclear factor of activated T-cells (Cn-NFAT) signalling pathway in the regulation of activity-dependent fibre type switching in adult mammalian skeletal muscles, little is known about the endogenous expression of NFAT proteins in the various fibre typ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.040485
更新日期:2008-03-01 00:00:00
abstract::The hallmark of epithelial cells is their functional polarization. It is those membrane proteins that are distributed differentially, either to the apical or to the basal surface, that determine epithelial physiology. Such proteins will include 'pumps', 'channels' and 'carriers', and it is the functional interplay bet...
journal_title:Experimental physiology
pub_type:
doi:10.1113/expphysiol.2007.037523
更新日期:2008-03-01 00:00:00
abstract::The pattern of propagation of slow waves in the small intestine is not clear. Specifically, it is not known whether propagation is determined by a single dominant ICC-MP (Interstitial cells of Cajal located in the Myenteric Plexus) pacemaker unit or whether there are multiple active pacemakers. To determine this patte...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.039180
更新日期:2008-03-01 00:00:00
abstract::Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged physiological sodium deficiency in many animal species. The same neural mechanisms that are responsible for sodium appetite in laboratory animals may influence human behaviour as well, with particular relevance to the dietary salt intake...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2007.039891
更新日期:2008-02-01 00:00:00
abstract::Effects of altered maternal salt intake between 122 and 127 days gestation (term is 150 days) were studied in eight fetuses carried by ewes which had renal insufficiency caused by subtotal nephrectomy (STNxF) and seven fetuses carried by intact ewes (IntF). Plasma sodium and osmolality were increased in ewes with subt...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.039149
更新日期:2008-02-01 00:00:00
abstract::Aldosterone influences the kidney's regulation of blood pressure (BP), but aldosterone can contribute to the pathogenesis of hypertension. Blood pressure is reduced with aerobic exercise training (AEX), but the extent to which plasma aldosterone (PA) levels change is unclear. The purpose of this study was to determine...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.037408
更新日期:2007-09-01 00:00:00
abstract:UNLABELLED:The modulation of activity of the upper airway dilator and respiratory muscles plays a key role in the regulation of ventilation, but little is known about the link between their neuromuscular activation processes in vivo. This study investigated genioglossus and diaphragm responses to transcranial magnetic ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.037572
更新日期:2007-07-01 00:00:00
abstract::Non-invasive autonomic evaluation has used fast Fourier transform (FFT) to assign a range of low (LF) and high frequencies (HF) as markers of sympathetic and parasympathetic influences, respectively. However, FFT cannot be applied to brief transient phenomena, such as those observed on performing autonomic tests where...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.038026
更新日期:2007-07-01 00:00:00
abstract::The nucleus tractus solitarii (NTS) is a key central link in control of multiple homeostatic reflexes. A number of studies have demonstrated that exogenous and endogenous nitric oxide (NO) within NTS regulates visceral function, but further understanding of the role of NO in the NTS is hampered by the lack of informat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036103
更新日期:2007-03-01 00:00:00
abstract::This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.035089
更新日期:2007-03-01 00:00:00
abstract::It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.035972
更新日期:2007-03-01 00:00:00
abstract::It is unclear whether cardiac hypertrophy and hypertrophy-related pathways will be induced by long-term intermittent hypoxia. Thirty-six Sprague-Dawley rats were randomly assigned into three groups: normoxia, and long-term intermittent hypoxia (12% O(2), 8 h per day) for 4 weeks (4WLTIH) or for 8 weeks (8WLTIH). Myoca...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036590
更新日期:2007-03-01 00:00:00